Mechanisms underlying fatigue...

**bernard** · 03-03-2005, 07:09 AM

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15461817

BMC Neurol. 2004 Oct 04;4(1):14.
Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.

Okada T, Tanaka M, Kuratsune H, Watanabe Y, Sadato N.

National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan. tomokada@ibri-kobe.org <tomokada@ibri-kobe.org>

BACKGROUND: Fatigue is a crucial sensation that triggers rest, yet its underlying neuronal mechanisms remain unclear. Intense long-term fatigue is a symptom of chronic fatigue syndrome, which is used as a model to study the mechanisms underlying fatigue. METHODS: Using magnetic resonance imaging, we conducted voxel-based morphometry of 16 patients and 49 age-matched healthy control subjects. RESULTS: We found that patients with chronic fatigue syndrome had reduced gray-matter volume in the bilateral prefrontal cortex. Within these areas, the volume reduction in the right prefrontal cortex paralleled the severity of the fatigue of the subjects. CONCLUSION: These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue.

PMID: 15461817 [PubMed - in process]

I hope that RIN will like this one! :wink:

**bernard** · 03-03-2005, 07:24 AM

Here is the PDF version
http://www.somasimple.com/pdf_files/chronic_fatigue.pdf

03-03-2005, 07:09 AM	#1
bernard Admin, Moderator... Join Date: Mar 2004 Location: France Age: 56 Posts: 12,015 Thanks: 244 Thanked 142 Times in 93 Posts	Mechanisms underlying fatigue... http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15461817 BMC Neurol. 2004 Oct 04;4(1):14. Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome. Okada T, Tanaka M, Kuratsune H, Watanabe Y, Sadato N. National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan. tomokada@ibri-kobe.org <tomokada@ibri-kobe.org> BACKGROUND: Fatigue is a crucial sensation that triggers rest, yet its underlying neuronal mechanisms remain unclear. Intense long-term fatigue is a symptom of chronic fatigue syndrome, which is used as a model to study the mechanisms underlying fatigue. METHODS: Using magnetic resonance imaging, we conducted voxel-based morphometry of 16 patients and 49 age-matched healthy control subjects. RESULTS: We found that patients with chronic fatigue syndrome had reduced gray-matter volume in the bilateral prefrontal cortex. Within these areas, the volume reduction in the right prefrontal cortex paralleled the severity of the fatigue of the subjects. CONCLUSION: These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue. PMID: 15461817 [PubMed - in process] I hope that RIN will like this one! :wink: __________________ Simplicity is the ultimate sophistication. L VINCI We are to admit no more causes of natural things than such as are both true and sufficient to explain their appearances. I NEWTON Everything should be made as simple as possible, but not a bit simpler. If you can't explain it simply, you don't understand it well enough. Albert Einstein bernard

03-03-2005, 07:24 AM	#2
bernard Admin, Moderator... Join Date: Mar 2004 Location: France Age: 56 Posts: 12,015 Thanks: 244 Thanked 142 Times in 93 Posts	Here is the PDF version http://www.somasimple.com/pdf_files/chronic_fatigue.pdf __________________ Simplicity is the ultimate sophistication. L VINCI We are to admit no more causes of natural things than such as are both true and sufficient to explain their appearances. I NEWTON Everything should be made as simple as possible, but not a bit simpler. If you can't explain it simply, you don't understand it well enough. Albert Einstein bernard

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