Ref Nonobvious human disease models

[Jon Newman]

I'm working on interpreting what the paper, Systematic discovery of nonobvious human disease models through orthologous phenotypes, is conveying. I'll post some of what I learn here for anyone interested. If anyone has a good handle on the subject matter, please chime in.

My first stumbling block was the title itself. What's an orthologous phenotype?

Here's the wikipedia entry on orthology.

For good measure, here's the entry on phenotype.

[smikolic]

Neat find!

I remember wondering how they were thinking of sorting through all that DNA evidence to find the contributors to disease/disorders and "abnormal" genes w/all the various genomes/phenotypes etc the human being holds in multitude form and fashion....

Wonder if they are looking to use this to enhance the search.....trying to recognize commonalities to increase recognition in human models and to aid genome study and interpretation for example.....did you get that out of your reading, Jon?

[Jon Newman]

Originally Posted by smikolic

Wonder if they are looking to use this to enhance the search.....trying to recognize commonalities to increase recognition in human models and to aid genome study and interpretation for example.....did you get that out of your reading, Jon?

My reading is going to be slow, exploratory and essentially hobby like. I did get the idea that this approach would open up new avenues of exploration in molecular medicine.