|03-03-2005, 07:09 AM||#1|
Join Date: Mar 2004
Thanked 465 Times in 236 Posts
Mechanisms underlying fatigue...
BMC Neurol. 2004 Oct 04;4(1):14.
Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.
Okada T, Tanaka M, Kuratsune H, Watanabe Y, Sadato N.
National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan. firstname.lastname@example.org <email@example.com>
BACKGROUND: Fatigue is a crucial sensation that triggers rest, yet its underlying neuronal mechanisms remain unclear. Intense long-term fatigue is a symptom of chronic fatigue syndrome, which is used as a model to study the mechanisms underlying fatigue. METHODS: Using magnetic resonance imaging, we conducted voxel-based morphometry of 16 patients and 49 age-matched healthy control subjects. RESULTS: We found that patients with chronic fatigue syndrome had reduced gray-matter volume in the bilateral prefrontal cortex. Within these areas, the volume reduction in the right prefrontal cortex paralleled the severity of the fatigue of the subjects. CONCLUSION: These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue.
PMID: 15461817 [PubMed - in process]
I hope that RIN will like this one! :wink:
Simplicity is the ultimate sophistication. L VINCI
We are to admit no more causes of natural things than such as are both true and sufficient to explain their appearances. I NEWTON
Everything should be made as simple as possible, but not a bit simpler.
If you can't explain it simply, you don't understand it well enough. Albert Einstein
|Thread||Thread Starter||Forum||Replies||Last Post|
|Neural Mechanisms of Persistent Pain||emad||PPP Management||21||27-09-2006 06:19 PM|
|Manipulation's Mechanisms on EIM||Jason Silvernail||Barrett's Forums||2||18-08-2006 06:27 PM|